A mechanism of action of phenylephrine on heart.
Indian J Physiol Pharmacol
;
1977 Jul-Sep; 21(3): 167-74
Artículo
en Inglés
| IMSEAR
| ID: sea-108901
ABSTRACT
Phenylephrine exerted a positive chronotropic and inotropic effect on isolated, spontaneously beating, atria of reserpinised rabbits. Addition of phenoxybenzamine and phentolamine resulted in a depression of control contractile amplitude. Practolol, however, was devoid of this effect. The positive inotropic response to phenylephrine was significantly antagonised by all the three blockers used, while positive chronotropic response was annulled by phentolamine and practolol, but not with phenoxybenzamine. It is, therefore, suggested that phenylephrine exerts its cardiostimulant effects through mediation of both alpha and beta-1 adrenoceptors. A probable mechanism of action could be, that phenylephrine acts on some specific chemical group, shared by alpha and beta1 receptors. This specific group is probably blocked by both alpha and betaceptor antagonists separately, so phenylephrine becomes ineffective in presence of these antagonists.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fenoxibenzamina
/
Fentolamina
/
Fenilefrina
/
Practolol
/
Conejos
/
Estimulación Química
/
Femenino
/
Masculino
/
Frecuencia Cardíaca
/
Animales
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1977
Tipo del documento:
Artículo
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