The reversal by metoclopramide of apomorphine-induced inhibition of responses to stimulation of the cardioaccelerator nerves in the cat.
Indian J Physiol Pharmacol
;
1984 Jan-Mar; 28(1): 15-20
Artículo
en Inglés
| IMSEAR
| ID: sea-108911
ABSTRACT
The effect of metoclopramide on presynaptic dopamine receptors was investigated in the cat cardioaccelerator nerve preparation. Metoclopramide, a substituted benzamide derivative, antagonized inhibitory action of apomorphine on positive chronotropic responses induced by sympathetic nerve stimulation in cat hearts, in vivo. Neither phentolamine, an alpha-adrenergic blocking agent, nor indomethacin a prostaglandin synthesis inhibitor, antagonized the effect of apomorphine. Apomorphine did not alter the positive chronotropic effects of intravenously administered noradrenaline. Metoclopramide potentiated stimulation-induced positive chronotropic responses. These results suggest that metoclopramide blocks the presynaptic dopamine receptors at the cat heart.
Texto completo:
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Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fentolamina
/
Sistema Nervioso Simpático
/
Femenino
/
Masculino
/
Apomorfina
/
Norepinefrina
/
Gatos
/
Indometacina
/
Receptores Dopaminérgicos
/
Estimulación Eléctrica
Idioma:
Inglés
Revista:
Indian J Physiol Pharmacol
Año:
1984
Tipo del documento:
Artículo
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