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Mechanism of action of 6, 7, 8, 9, 10, 12-hexahydro-azepino-[2, 1-b] quinazolin-12-one-(RLX)--a novel bronchodilator.
Indian J Physiol Pharmacol ; 2000 Jan; 44(1): 75-81
Artículo en Inglés | IMSEAR | ID: sea-108959
ABSTRACT
The present study presents a mode of action profile of RLX (6, 7, 8, 9, 10, 12-hexahydro-azepino-[2, 1-b]-quinazoline-12-one) a bronchodilator obtained by the chemical modification in the molecule of alkaloid vasicine (Ex Adhatoda vesica). The effect of RLX (p.o.) was observed on (a) mast cell degranulation, (b) release of histamine and prostaglandin E (PGE), (c) 45Ca uptake and (d) activities of cAMP phosphodiesterase (PDEase) and lipoxygenase enzymes in mesenteries/peritoneal mast cells/lung tissue homogenates in rats under systemic anaphylaxis. RLX (10 and 20 mg/kg) inhibited antigen-induced mast cell degranulation and released of histamine from target tissues. An increased outflow of PGE (lungs) and an inhibited 45Ca uptake (peritoneal mast cells) were noted. Lung PDEase and lipoxygenase activities were decreased. These results suggested that RLX could be acting like disodium cromoglycate and aminophyline with additional attributes its oral efficacy and long duration of action.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Quinazolinas / Ratas / Broncodilatadores / Masculino / Degranulación de la Célula / Calcio / Electroforesis en Gel de Poliacrilamida / Liberación de Histamina / Caballos / Hipersensibilidad Idioma: Inglés Revista: Indian J Physiol Pharmacol Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Quinazolinas / Ratas / Broncodilatadores / Masculino / Degranulación de la Célula / Calcio / Electroforesis en Gel de Poliacrilamida / Liberación de Histamina / Caballos / Hipersensibilidad Idioma: Inglés Revista: Indian J Physiol Pharmacol Año: 2000 Tipo del documento: Artículo