Molecular genetics of schizophrenia: past, present and future.
J Biosci
;
2002 Feb; 27(1 Suppl 1): 35-52
Artículo
en Inglés
| IMSEAR
| ID: sea-110752
ABSTRACT
Schizophrenia is a severe neuropsychiatric disorder with a polygenic mode of inheritance which is also governed by non-genetic factors. Candidate genes identified on the basis of biochemical and pharmacological evidence are being tested for linkage and association studies. Neurotransmitters, especially dopamine and serotonin have been widely implicated in its etiology. Genome scan of all human chromosomes with closely spaced polymorphic markers is being used for linkage studies. The completion and availability of the first draft of Human Genome Sequence has provided a treasure-trove that can be utilized to gain insight into the so far inaccessible regions of the human genome. Significant technological advances for identification of single nucleo-tide polymorphisms (SNPs) and use of microarrays have further strengthened research methodologies for genetic analysis of complex traits. In this review, we summarize the evolution of schizophrenia genetics from the past to the present, current trends and future direction of research.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Proteínas de Transporte de Membrana
/
Esquizofrenia
/
Tirosina 3-Monooxigenasa
/
Humanos
/
Glicoproteínas de Membrana
/
Catecol O-Metiltransferasa
/
Genoma Humano
/
Cromosomas Humanos
/
Receptores de Serotonina
/
Receptores Dopaminérgicos
Tipo de estudio:
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
J Biosci
Año:
2002
Tipo del documento:
Artículo
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