The p53-MDM2 network: from oscillations to apoptosis.
J Biosci
;
2007 Aug; 32(5): 991-7
Artículo
en Inglés
| IMSEAR
| ID: sea-110800
ABSTRACT
The p53 protein is well-known for its tumour suppressor function. The p53-MDM2 negative feedback loop constitutes the core module of a network of regulatory interactions activated under cellular stress. In normal cells, the level of p53 proteins is kept low by MDM2, i.e. MDM2 negatively regulates the activity of p53. In the case of DNA damage, the p53-mediated pathways are activated leading to cell cycle arrest and repair of the DNA. If repair is not possible due to excessive damage, the p53-mediated apoptotic pathway is activated bringing about cell death. In this paper, we give an overview of our studies on the p53-MDM2 module and the associated pathways from a systems biology perspective.We discuss a number of key predictions, related to some specific aspects of cell cycle arrest and cell death, which could be tested in experiments.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Relojes Biológicos
/
Humanos
/
Transducción de Señal
/
Proteína p53 Supresora de Tumor
/
Apoptosis
/
Biología de Sistemas
/
Proteínas Proto-Oncogénicas c-mdm2
/
Animales
Idioma:
Inglés
Revista:
J Biosci
Año:
2007
Tipo del documento:
Artículo
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