Human seminal proteinase and prostate-specific antigen are the same protein.
J Biosci
;
2008 Jun; 33(2): 195-207
Artículo
en Inglés
| IMSEAR
| ID: sea-110842
ABSTRACT
Human seminal proteinase and prostate-specific antigen (PSA) were each isolated from human seminal fluid and compared. Both are glycoproteins of 32-34 kDa with protease activities. Based on some physicochemical,enzymatic and immunological properties,it is concluded that these proteins are in fact identical.The protein exhibits properties similar to kallikrein-like serine protease, trypsin,chymotrypsin and thiol acid protease.Tests of the activity of the enzyme against some potential natural and synthetic substrates showed that bovine serum albumin was more readily hydrolysed than casein.The results of this study should be useful in purifying and assaying this protein.Based on published studies and the present results,the broad proteolytic specificity of human seminal proteinase suggests a role for this protein in several physiological functions.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Péptido Hidrolasas
/
Semen
/
Mapeo Peptídico
/
Humanos
/
Masculino
/
Cromatografía en Gel
/
Cromatografía por Intercambio Iónico
/
Antígeno Prostático Específico
/
Electroforesis en Gel de Poliacrilamida
Idioma:
Inglés
Revista:
J Biosci
Año:
2008
Tipo del documento:
Artículo
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