Application of InterPro for the functional classification of the proteins of fish origin in SWISS-PROT and TrEMBL.
J Biosci
;
2001 Jun; 26(2): 277-84
Artículo
en Inglés
| IMSEAR
| ID: sea-110917
ABSTRACT
InterPro (http//www.ebi.ac.uk/interpro/) is an integrated documentation resource for protein families, domains and sites, developed initially as a means of rationalizing the complementary efforts of the PROSITE, PRINTS, Pfam and ProDom database projects. It is a useful resource that aids the functional classification of proteins. Almost 90% of the actinopterygii protein sequences from SWISS-PROT and TrEMBL can be classified using InterPro. Over 30% of the actinopterygii protein sequences currently in SWISS-PROT and TrEMBL are of mitochondrial origin, the majority of which belong to the cytochrome b/b6 family. InterPro also gives insights into the domain composition of the classified proteins and has applications in the functional classification of newly determined sequences lacking biochemical characterization, and in comparative genome analysis. A comparison of the actinopterygii protein sequences against the sequences of other eukaryotes confirms the high representation of eukaryotic protein kinase in the organisms studied. The comparisons also show that, based on InterPro families, the trans-species evolution of MHC class I and II molecules in mammals and teleost fish can be recognized.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Proteínas
/
Bases de Datos Factuales
/
Gestión de la Información
/
Internet
/
Análisis de Secuencia de Proteína
/
Peces
/
Animales
Idioma:
Inglés
Revista:
J Biosci
Año:
2001
Tipo del documento:
Artículo
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