Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNA.
J Biosci
;
2002 Feb; 27(1 Suppl 1): 53-65
Artículo
en Inglés
| IMSEAR
| ID: sea-111107
ABSTRACT
Fourteen genetic neurodegenerative diseases and three fragile sites have been associated with the expansion of (CTG)n (CAG)n, (CGG)n (CCG)n, or (GAA)n (TTC)n repeat tracts. Different models have been proposed for the expansion of triplet repeats, most of which presume the formation of alternative DNA structures in repeat tracts. One of the most likely structures, slipped strand DNA, may stably and reproducibly form within triplet repeat sequences. The propensity to form slipped strand DNA is proportional to the length and homogeneity of the repeat tract. The remarkable stability of slipped strand DNA may, in part, be due to loop-loop interactions facilitated by the sequence complementarity of the loops and the dynamic structure of three-way junctions formed at the loop-outs.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
ADN
/
Microscopía de Fuerza Atómica
/
Repeticiones de Trinucleótidos
/
Enfermedades Neurodegenerativas
/
Expansión de Repetición de Trinucleótido
/
Modelos Genéticos
/
Mutación
/
Conformación de Ácido Nucleico
Idioma:
Inglés
Revista:
J Biosci
Año:
2002
Tipo del documento:
Artículo
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