Type 1 (11;22)(q24:q12) translocation is common in Ewing's sarcoma/peripheral neuroectodermal tumour in south Indian patients.
J Biosci
;
2005 Jun; 30(3): 371-6
Artículo
en Inglés
| IMSEAR
| ID: sea-111269
ABSTRACT
The Ewing's sarcoma family can present diagnostic difficulties. In the past the basis of diagnosis has been a exclusion. Identification of a specific translocation especially t(11;22) (EWS-FLI 1 fusion gene), which is seen in nearly 85 percent of Ewing's sarcoma cases can help in precise diagnosis. We have carried out a study on twenty patient samples diagnosed to have Ewing's sarcoma/peripheral neuroectodermal tumour (PNET)/small round cell malignant tumour. The study involved RT-PCR analysis for the fusion transcript, followed by sequencing to identify the specific type of fusion. Ninety percent (18/20) of the samples tested were found to be t(11;22) translocations involving EWS-FLI 1 genes. Sixty-one percent (11/18) were found to be type 1 fusion and seven were type 2 (39 percentage). This is the first study in India with quantitative information about the types of EWS-FLI 1 translocations present in Ewing's family of tumours in south Indian patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Sarcoma de Ewing
/
Factores de Transcripción
/
Translocación Genética
/
Cromosomas Humanos Par 11
/
Cromosomas Humanos Par 22
/
Femenino
/
Humanos
/
Masculino
/
Proteínas de Fusión Oncogénica
/
Niño
Tipo de estudio:
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
J Biosci
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS