Tyrosine phosphorylation of the human guanylyl cyclase C receptor.
J Biosci
;
2000 Dec; 25(4): 339-46
Artículo
en Inglés
| IMSEAR
| ID: sea-111272
ABSTRACT
Tyrosine phosphorylation events are key components of several cellular signal transduction pathways. This study describes a novel method for identification of substrates for tyrosine kinases. Co-expression of the tyrosine kinase EphB1 with the intracellular domain of guanylyl cyclase C (GCC) in Escherichia coli cells resulted in tyrosine phosphorylation of GCC, indicating that GCC is a potential substrate for tyrosine kinases. Indeed, GCC expressed in mammalian cells is tyrosine phosphorylated, suggesting that tyrosine phosphorylation may play a role in regulation of GCC signalling. This is the first demonstration of tyrosine phosphorylation of any member of the family of membrane-associated guanylyl cyclases.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fosforilación
/
Plásmidos
/
Tirosina
/
Mapeo Peptídico
/
Proteínas Recombinantes de Fusión
/
Humanos
/
Inmunoglobulina G
/
Pruebas de Precipitina
/
Transducción de Señal
/
Línea Celular
Idioma:
Inglés
Revista:
J Biosci
Año:
2000
Tipo del documento:
Artículo
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