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The role of microRNAs (miRNA) in circadian rhythmicity.
J Genet ; 2008 Dec; 87(5): 505-11
Artículo en Inglés | IMSEAR | ID: sea-114228
ABSTRACT
MicroRNA (miRNA) is a recently discovered new class of small RNA molecules that have a significant role in regulating gene and protein expression. These small RNAs (approximately 22 nt) bind to 3' untranslated regions (3'UTRs) and induce degradation or repression of translation of their mRNA targets. Hundreds of miRNAs have been identified in various organisms and have been shown to play a significant role in development and normal cell functioning. Recently, a few studies have suggested that miRNAs may be an important regulators of circadian rhythmicity, providing a new dimension (posttranscriptional) of our understanding of biological clocks. Here, we describe the mechanisms of miRNA regulation, and recent studies attempting to identify clock miRNAs and their function in the circadian system.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Biosíntesis de Proteínas / Relojes Biológicos / Humanos / Datos de Secuencia Molecular / Secuencia de Bases / Procesamiento Postranscripcional del ARN / Ritmo Circadiano / MicroARNs / Animales / Modelos Biológicos Idioma: Inglés Revista: J Genet Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Biosíntesis de Proteínas / Relojes Biológicos / Humanos / Datos de Secuencia Molecular / Secuencia de Bases / Procesamiento Postranscripcional del ARN / Ritmo Circadiano / MicroARNs / Animales / Modelos Biológicos Idioma: Inglés Revista: J Genet Año: 2008 Tipo del documento: Artículo