A comparison of two popular statistical methods for estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences.
J Genet
;
2003 Apr-Aug; 82(1-2): 7-12
Artículo
en Inglés
| IMSEAR
| ID: sea-114344
ABSTRACT
We have compared two statistical methods of estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences, which have been proposed by Templeton (1993) and Bandelt et al. (1995). Monte-Carlo simulations were used for generating DNA sequence data. Different evolutionary scenarios were simulated and the estimation procedures were evaluated. We have found that for both methods (i) the estimates are insensitive to demographic parameters and (ii) the standard deviations of the estimates are too high for these methods to be reliably used in practice.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Factores de Tiempo
/
Algoritmos
/
Simulación por Computador
/
Humanos
/
ADN
/
Demografía
/
Método de Montecarlo
/
Estadística como Asunto
/
Evolución Molecular
/
Animales
Tipo de estudio:
Evaluación Económica en Salud
/
Estudio pronóstico
Idioma:
Inglés
Revista:
J Genet
Año:
2003
Tipo del documento:
Artículo
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