Cardiovascular involvement in systemic lupus erythematosus: an autopsy study of 27 patients in India.
J Postgrad Med
;
2006 Jan-Mar; 52(1): 5-10; discussion 10
Artículo
en Inglés
| IMSEAR
| ID: sea-115525
ABSTRACT
BACKGROUND:
Although cardiovascular disease (CVD) is recognized as a leading cause of death in patients with systemic lupus erythematosus (SLE) in western countries, there is hardly any data regarding Indian subjects with SLE.AIMS:
To determine the incidence of cardiac abnormalities and vascular lesions at autopsy and to assess their contribution to the mortality in patients with SLE. SETTINGS ANDDESIGN:
Retrospective retrieval of reports of autopsies performed on 35 patients with SLE over a 11 year period and analysis of 27 cases with cardiac and/or vascular lesions. MATERIALS ANDMETHODS:
Gross and microscopic features in 27 autopsies were analyzed with special attention to the heart and the vasculature of all organs. Findings were correlated with clinical features and ante-mortem investigations. Their contribution towards mortality was assessed.RESULTS:
Valvar lesions were the commonest cardiac lesions noted with non-bacterial thrombotic endocarditis in nine (33.33%), valvar thickening in two (7.41%), Libman-Sacks endocarditis and infective endocarditis in one (3.70%) each. Myocarditis and myocardial scarring were seen in 10 (37.03%) and seven (25.92%) cases, respectively. Fibrinous pericarditis was noted in seven (25.92%). Thromboses/embolism, vasculitis and severe coronary atherosclerosis were seen in nine (33.33%), five (18.52%) and one (3.70%) subjects, respectively. Renal disease [13, 48.14%] and cardiovascular manifestations [8, 29.62%] were the leading causes of death in our patient population.CONCLUSION:
CVD contributes significantly to the mortality in patients with SLE in India. It is second only to renal disease in this regard.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Autopsia
/
Femenino
/
Humanos
/
Masculino
/
Enfermedades Cardiovasculares
/
Niño
/
Incidencia
/
Estudios Retrospectivos
/
Adolescente
/
Adulto
Tipo de estudio:
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
J Postgrad Med
Año:
2006
Tipo del documento:
Artículo
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