An analysis of children with typhoid fever admitted in 1991.
J Postgrad Med
;
1994 Oct-Dec; 40(4): 204-7
Artículo
en Inglés
| IMSEAR
| ID: sea-116861
ABSTRACT
In 28 children, with bacteriologically and/or serologically diagnosed typhoid fever treated at KEM Hospital, Bombay in 1991, initially one of the three recommended drugs (viz. chloramphenicol, amoxycillin or co-trimoxazole) was given for 7 days for defervescence to occur. In those who failed to respond, a second trial of therapy with one of the other two drugs was initiated, after omitting the first drug. A second failure of therapy was taken as an indication to use ciprofloxacin singly. Eventually, 18 (64.3%) cases responded to chloramphenicol or amoxycillin or co-trimoxazole. Ciprofloxacin was used in 19(35.7%) cases. the failure rate of treatment with chloramphenicol was 50%, with amoxycillin 71.4%, with co-trimoxazole 75% and 0% with ciprofloxacin. An analysis of the 28 cases revealed that apart from fever (in 100%), splenomegaly (in 82.1%) was the most important clinical pointer to diagnosis, along with absolute eosinopenia (in 71.4%). There were no major complications, except 2 cases with typhoid hepatitis who responded to choramphenicol and co-trimoxazole, respectively. Blood culture grew Salmonella typhi in 7 cases, of which 5 (72%) were multidrug resistant S. typhi. There were no characteristic clinical features to identify multi-drug resistant typhoid fever.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Penicilinas
/
Esplenomegalia
/
Fiebre Tifoidea
/
Humanos
/
Ciprofloxacina
/
Combinación Trimetoprim y Sulfametoxazol
/
Niño
/
Amoxicilina
/
Antiinfecciosos
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
J Postgrad Med
Año:
1994
Tipo del documento:
Artículo
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