Concomitant acral necrosis and haemolytic uraemic syndrome following ingestion of quinine.
J Postgrad Med
;
2002 Jul-Sep; 48(3): 197-8
Artículo
en Inglés
| IMSEAR
| ID: sea-117284
ABSTRACT
Thrombotic microangiopathy, which broadly includes thrombotic thrombocytopaenic purpura (TTP) and haemolytic uraemic syndrome (HUS), is a multisystemic disorder that is characterised by thrombocytopaenia, microangiopathic haemolytic anemia and ischaemic manifestations, resulting from platelet agglutination in the arterial microvasculature. Acral necrosis (distal necrosis of fingers and toes) occurs usually as a sequel to severe Raynaud's phenomenon, a vasculospastic disorder frequently related to endothelial cell dysfunction. We report a case of quinine induced TTP-HUS and acral necrosis, two distinct clinical abnormalities which have not yet been reported together in association with quinine. Both of these conditions in this case resolved promptly to treatment with corticosteroids.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Púrpura Trombocitopénica Trombótica
/
Quinina
/
Biopsia con Aguja
/
Anciano
/
Humanos
/
Masculino
/
Inmunohistoquímica
/
Dedos del Pie
/
Estudios de Seguimiento
/
Resultado del Tratamiento
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
J Postgrad Med
Año:
2002
Tipo del documento:
Artículo
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