Thyroid cancer in toxic and non-toxic multinodular goiter.
J Postgrad Med
;
2007 Jul-Sep; 53(3): 157-60
Artículo
en Inglés
| IMSEAR
| ID: sea-117417
ABSTRACT
BACKGROUND:
Many authors have claimed that hyperthyroidism protects against thyroid cancer and believed that the incidence of malignancy is lower in patients with toxic multinodular goiter (TMG) than in those with non-toxic multinodular goiter. But in recent studies, it was reported that the incidence of malignancy with TMG is not as low as previously thought.AIM:
To compare the thyroid cancer incidence in patients with toxic and non-toxic multinodular goiter. SETTINGS ANDDESIGN:
Histology reports of patients treated surgically with a preoperative diagnosis of toxic and non-toxic multinodular goiter were reviewed to identify the thyroid cancer incidence. Patients having a history of neck irradiation or radioactive iodine therapy were excluded from the study. MATERIALS ANDMETHODS:
We reviewed 294 patients operated between 2001-2005 from toxic and non-toxic multinodular goiter. One hundred and twenty-four of them were toxic and 170 were non-toxic. Hyperthyroidism was diagnosed by elevated tri-iodothyroinine / thyroxine ratios and low thyroid-stimulating hormone with clinical signs and symptoms. All patients were evaluated with ultrasonography and scintigraphy and fine needle aspiration biopsy. STATISTICAL ANALYSIS USED Significance of the various parameters was calculated by using ANOVA test.RESULTS:
The incidence of malignancy was 9% in the toxic and 10.58% in the non-toxic multinodular goiter group. Any significant difference in the incidence of cancer and tumor size between the two groups could not be detected.CONCLUSIONS:
The incidence of malignancy in toxic multinodular goiter is not very low as thought earlier and is nearly the same in non-toxic multinodular goiter.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
Neoplasias de la Tiroides
/
Carcinoma Papilar
/
Estudios Retrospectivos
/
Carcinoma Papilar Folicular
/
Adenoma Oxifílico
/
Bocio Nodular
/
Hipertiroidismo
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
J Postgrad Med
Año:
2007
Tipo del documento:
Artículo
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