Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy.
Neurol India
;
2003 Sep; 51(3): 367-9
Artículo
en Inglés
| IMSEAR
| ID: sea-120661
ABSTRACT
The reading frame hypothesis has been proposed to explain the molecular basis of two allelic forms of muscular dystrophies, Duchenne/Becker muscular dystrophy (D/BMD). To evaluate the hypothesis in Indian D/BMD patients, we analyzed deletion of dystrophin exons in 147 DMD and 19 BMD patients. Our studies showed deviation of more than 30% from the reading frame hypothesis in DMD patients (47/147). The present results implicate a need to reevaluate the reading frame hypothesis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fenotipo
/
Humanos
/
Masculino
/
Niño
/
Distrofina
/
Mutación del Sistema de Lectura
/
Eliminación de Gen
/
Distrofia Muscular de Duchenne
/
Genotipo
Idioma:
Inglés
Revista:
Neurol India
Año:
2003
Tipo del documento:
Artículo
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