Epstein-Barr virus as a possible etiologic agent in primary central nervous system lymphoma in immunocompetent individuals.
Neurol India
;
2009 Jan-Feb; 57(1): 36-40
Artículo
en Inglés
| IMSEAR
| ID: sea-121124
ABSTRACT
BACKGROUND:
Primary central nervous system lymphoma (PCNSL) occurs in both immunocompetent and immunosuppressed individuals. The role of Epstein-Barr virus (EBV) has been implicated in immunosuppressed individuals but its role is not established in immunocompetent individuals.AIMS:
To study the possible role of EBV in PCNSL in immunocompetent individuals. SETTING ANDDESIGN:
Retrospective study. Materials andMethods:
Thirty patients with PCNSL were studied immunohistochemically with antibodies to CD45, CD20, CD3 and EBV latent membrane protein-1 (EBV LMP-1). In situ hybridization was done in 19 patients where enough tissue was available using a specific oligonucleotide probe for EBV-Early RNA (EBER).RESULTS:
All the patients were immunocompetent and mean age was 41.6 years. Histologically they were diffuse large cell lymphoma 25 (83.3%) were B cell, 1(3.3%) was T cell and 4 (13.3%) were unclassified. EBV LMP-1 showed variable membrane and cytoplasmic positivity in 24 (80%) patients. In situ hybridization for EBER was negative in all the 19 patients studied.CONCLUSION:
In this region of the world probably EBV has no etiologic role in PCNSL in immunocompetent individuals.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
Idioma:
Inglés
Revista:
Neurol India
Año:
2009
Tipo del documento:
Artículo
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