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Epstein-Barr virus as a possible etiologic agent in primary central nervous system lymphoma in immunocompetent individuals.
Neurol India ; 2009 Jan-Feb; 57(1): 36-40
Artículo en Inglés | IMSEAR | ID: sea-121124
ABSTRACT

BACKGROUND:

Primary central nervous system lymphoma (PCNSL) occurs in both immunocompetent and immunosuppressed individuals. The role of Epstein-Barr virus (EBV) has been implicated in immunosuppressed individuals but its role is not established in immunocompetent individuals.

AIMS:

To study the possible role of EBV in PCNSL in immunocompetent individuals. SETTING AND

DESIGN:

Retrospective study. Materials and

Methods:

Thirty patients with PCNSL were studied immunohistochemically with antibodies to CD45, CD20, CD3 and EBV latent membrane protein-1 (EBV LMP-1). In situ hybridization was done in 19 patients where enough tissue was available using a specific oligonucleotide probe for EBV-Early RNA (EBER).

RESULTS:

All the patients were immunocompetent and mean age was 41.6 years. Histologically they were diffuse large cell lymphoma 25 (83.3%) were B cell, 1(3.3%) was T cell and 4 (13.3%) were unclassified. EBV LMP-1 showed variable membrane and cytoplasmic positivity in 24 (80%) patients. In situ hybridization for EBER was negative in all the 19 patients studied.

CONCLUSION:

In this region of the world probably EBV has no etiologic role in PCNSL in immunocompetent individuals.
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Tipo de estudio: Estudio de etiología / Estudio observacional Idioma: Inglés Revista: Neurol India Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Tipo de estudio: Estudio de etiología / Estudio observacional Idioma: Inglés Revista: Neurol India Año: 2009 Tipo del documento: Artículo