Effect of eradication of Helicobacter pylori on gastric antrum histology.
Artículo
en Inglés
| IMSEAR
| ID: sea-124100
ABSTRACT
BACKGROUND:
Helicobacter pylori is a leading cause of gastritis. Some of the histological changes revert after eradication of H. pylori. There is paucity of reports from India.AIM:
To study the effect of H. pylori eradication on the histopathological changes.METHODS:
Endoscopically obtained antral biopsies from 164 consecutive H. pylori positive cases of dyspepsia were analysed before and 4 weeks after completion of treatment.RESULTS:
Treatment for H. pylori resulted in eradication of the organism as confirmed histologically in 123 out of 164 (76.22%) cases. Analysis of histopathological changes in pre and post treatment biopsies from the same patient revealed a significant reduction in neutrophils, eosinophils, chronic inflammatory cells, acute epithelial changes and regenerative foveolar hyperplasia (p < 0.001) There was no difference in these findings in cases where H. pylori eradication failed when compared with their pre-treatment biopsies (p > 0.05). Similarly the pre and post treatment biopsies revealed, no difference in frequency of intestinal metaplasia and gastric atrophy in cases where H. pylori was eradicated or persisted after treatment.CONCLUSION:
There was significant reduction in neutrophils, eosinophils, chronic inflammatory cells, acute epithelial changes and regenerative foveolar hyperplasia, following eradication of H. pylori.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Antro Pilórico
/
Biopsia
/
Humanos
/
Estudios de Casos y Controles
/
Helicobacter pylori
/
Infecciones por Helicobacter
Tipo de estudio:
Estudio observacional
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
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