Role of histamine-2 receptor antagonists after simple closure of perforated duodenal ulcer--a double blind randomised, controlled study.
Artículo
en Inglés
| IMSEAR
| ID: sea-124875
ABSTRACT
INTRODUCTION:
Definitive surgery at the time of primary laparotomy for perforated duodenal ulcer is often deferred because of its increased morbidity. However simple closure alone is associated with a high rate of recurrence. In view of this H2 blockers have been administered along with simple closure to promote ulcer healing. Only 4 series have been published so far, all lacking either a control group or endoscopic follow up. The results are contradictory.AIMS:
This study was done to assess the effect of administration of H2 blockers after simple closure on ulcer healing in a randomised, controlled, double blind fashion.METHODS:
One hundred patients were entered in the study. Fifty patients randomly selected either received ranitidine or a placebo after simple closure. Follow up endoscopy was done at 1, 2 and 6 months. If persistence of ulcer was seen at 4 weeks, patients on placebo were converted to ranitidine and those on ranitidine were continued on the drug.RESULTS:
Endoscopically assessed rate of persistent or recurrent ulcer at 4 weeks was 39% in the ranitidine group and 29% in the placebo group. At 6 months the corresponding figures were 33% and 30% respectively. The differences between the two groups were not significant.CONCLUSIONS:
Ranitidine, therefore, does not appear to promote healing of a perforated duodenal ulcer after simple closure.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Úlcera Péptica Perforada
/
Ranitidina
/
Femenino
/
Humanos
/
Masculino
/
Niño
/
Método Doble Ciego
/
Administración Oral
/
Estudios Prospectivos
/
Estudios de Seguimiento
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Año:
1996
Tipo del documento:
Artículo
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