Experimental screening for anti-peptic ulcer activity of some Myanmar traditional medicine formulations

ABSTRACT

Four Myanmar traditional medicine formulations (TMFs), namely TMF-02, TMF-03A, TMF-03B and TMF-08, locally claimed to be useful in treating dyspepsia, were screened for anti-peptic ulcer activity employing two experimental in vivo test models in rats. Only TMF-02, TMF-03B and TMF-08 markedly reduced ulcer severity to the ulcer indices of 17.4, 15.6 and 14.5 respectively. These effects were comparable to cimetidine (13.8), while that of the negative control was 35.Measuring gastric juice acidity in rats employing pyloric ligation confirmed that these three drugs did reduce gastric acidity, particularly diminishing the free acid one-third and shifting gastric pH from 6 to 7.