Anti-inflammatory and analgesic effects of the methanol extract from " garcinia wallichii " choisy in animal models

ABSTRACT

Pharmacological studies were conducted with the methanol extract from Garcinia wallichii Choisy (GW extract) on experimental animals to evaluate anti-infl ammatory and analgesic activities. The GW extract was found to exert an inhibitory activity on the acute phase of infl ammation, as seen in EPP-induced ear edema as well as carrageenin- and arachidonic acid- induced hind paw edema in rats. The GW extract showed weak inhibitory activity on cotton pellet-induced granuloma formation; a chronic inflammatory model. The extract also showed very strong analgesic activity on both acetic acid-induced writhing response in mice and the tail-fl ick test in rats. The single high GW extract dose 3,000 mg/kg taken orally did not cause mortality or show any signs of toxicity or changes in the internal organs of rats, indicating the non-toxic nature of the extract. Chiang Mai Medical Journal 2009;48(3)105-115.