Cyfluthrin-induced nephrotoxicity in rats.

This study was designed to evaluate the nephrotoxic effect of cyfluthrin in rats. Cyfluthrin at 0ppm (control), 100ppm and 200ppm (test-groups) was administered orally for 15 weeks. The micronutrient level (iron, zinc, copper, and selenium), the nutritional status (total carbohydrate, total glucose, total protein, total amino acids, total lipid, and total cholesterol), the lipid peroxidation level (reduced glutathione and thiobarbiturate) and the antioxidant enzyme activities (glutathione peroxidase, glutathione reductase, catalase, and glucose-6-phosphate dehydrogenase) were estimated. The results were statistically compared (p<0.05) with the control. A significant decrease in the organ-to-body ratio was observed in the test groups. The concentration of the micronutrient in the test groups increased significantly. The total carbohydrate, total glucose, total amino acids, total lipids and total cholesterol showed a significant decrease in the test groups, but a significant increase was observed in the tissue protein level of the test groups. Lipid peroxidation was increased in the test groups as indicated by a significant increase in the thiobarbiturate level and a significant decrease in the reduced glutathione level. All the antioxidant enzymes studied increased significantly in the test groups when compared with the control. Cyfluthrin is nephrotoxic under continuous administration in rats.