-Tocopherol ameliorates cypermethrin-induced toxicity and oxidative stress in the nematode Caenorhabdtis elegans.
Indian J Biochem Biophys
;
2011 June; 48(3): 191-196
Artículo
en Inglés
| IMSEAR
| ID: sea-135319
ABSTRACT
Oxidative stress and other effects induced by cypermethrin (CYP, 15 mM) and their amelioration by -tocopherol (400 M) was studied in the nematode Caenorhabditis elegans. The worms exposed for 4 h to CYP showed increased levels of reactive oxygen species (46%), H2O2 (37%) and protein carbonyls (29%), accompanied by decreased lifespan and brood size. However, exposure to both CYP and a-tocopherol resulted in diminution of above alterations with the worms exhibiting relatively lower levels of ROS (30%), H2O2 (15%), protein carbonyls (14%), altered antioxidant enzyme activities and normal lifespan and brood size. The results suggest that CYP induces oxidative stress in C. elegans and the strategy of intervention with -tocopherol could be exploited to offset this induced oxidative stress.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Piretrinas
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Especies Reactivas de Oxígeno
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Caenorhabditis elegans
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Estrés Oxidativo
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Alfa-Tocoferol
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Carbonilación Proteica
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Peróxido de Hidrógeno
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Insecticidas
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Animales
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Antioxidantes
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
2011
Tipo del documento:
Artículo
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