The complexity of ToxT-dependent transcription in Vibrio cholerae.
Artículo
en Inglés
| IMSEAR
| ID: sea-135372
ABSTRACT
Vibrio cholerae is the causative agent of the disease cholera, characterized by profuse watery diarrhoea. Two of the main virulence factors associated with the disease are cholera toxin (CT) and toxin-coregulated pilus (TCP). Expression of CT and TCP is regulated via a complex cascade of factors that respond to environmental signals, but ultimately ToxT is the direct transcriptional activator of the genes encoding CT and TCP. Recent studies have begun to unveil the mechanisms behind ToxT-dependent transcription. We review current knowledge of transcriptional activation by ToxT and the environmental stimuli that allow ToxT to regulate virulence gene expression, resulting in cholera pathogenesis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Proteínas Bacterianas
/
Factores de Transcripción
/
Transcripción Genética
/
Vibrio cholerae
/
Humanos
/
Datos de Secuencia Molecular
/
Secuencia de Bases
/
Regulación Bacteriana de la Expresión Génica
/
Cólera
Idioma:
Inglés
Año:
2011
Tipo del documento:
Artículo
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