Association of aldosterone synthase (CYP11B2 C-344T) gene polymorphism & susceptibility to essential hypertension in a south Indian Tamil population.
Artículo
en Inglés
| IMSEAR
| ID: sea-135597
ABSTRACT
Background & objective:
Renin-angiotensin aldosterone system (RAAS) plays an important role in the regulation of blood pressure. Aldosterone, synthesized by aldosterone synthase in the adrenal cortex is encoded by the CYP11B2 gene. In this case-control study we examined the association between CYP11B2 C-344T polymorphism and essential hypertension in south Indian Tamil population.Methods:
The study was conducted in 406 hypertensive cases and 424 healthy controls from Tamil population. Genotyping was performed by PCR-restriction fragment length polymorphism method. Statistical analysis was performed by logistic regression analysis.Results:
The 344TT homozygous variant genotype (OR-1.8; 95% CI 1.1-2.8; P=0.02) and T allele (P=0.007) were found to be significantly associated with hypertension. In gender based analysis, the risk was significantly higher in male hypertensives (OR-1.8; 95% CI 1.0-3.6, P=0.05) but not in female subjects. Interpretation &conclusion:
A significant association between CYP11B2 gene polymorphism and essential hypertension was observed and the risk was confined to male subjects in south Indian Tamil population.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Sistema Renina-Angiotensina
/
Femenino
/
Humanos
/
Masculino
/
Etnicidad
/
Modelos Logísticos
/
Oportunidad Relativa
/
Cartilla de ADN
/
Citocromo P-450 CYP11B2
/
Adulto
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2010
Tipo del documento:
Artículo
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