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Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management.
Artículo en Inglés | IMSEAR | ID: sea-135653
ABSTRACT
Sperm DNA integrity is of vital importance for foetal development and birth of healthy offspring. Oxidative stress and consequent DNA damage are the major cause of decline in semen quality in men with varicocele. A preliminary study was conducted on 11 men with clinical varicocele who also had high levels of reactive oxygen species (ROS), to assess DNA damage in sperms and ROS levels before and after varicocelectomy. Varicocelectomy resulted in rapid (1 month) significant (P<0.001) decline in free radical levels and slow (3-6 months) significant decline in DNA damage levels. Thus men undergoing varicocelectomy should try concieving only 6 months following surgery.
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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Factores de Tiempo / Varicocele / Daño del ADN / Humanos / Masculino / Resultado del Tratamiento / Especies Reactivas de Oxígeno / Estrés Oxidativo / Infertilidad Masculina Idioma: Inglés Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Factores de Tiempo / Varicocele / Daño del ADN / Humanos / Masculino / Resultado del Tratamiento / Especies Reactivas de Oxígeno / Estrés Oxidativo / Infertilidad Masculina Idioma: Inglés Año: 2010 Tipo del documento: Artículo