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Protective association exhibited by the single nucleotide polymorphism (SNP) rs1052133 in the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head & neck (SCCHN) among north Indians.
Artículo en Inglés | IMSEAR | ID: sea-135703
ABSTRACT
Background &

objectives:

Imbalances in compactly regulated DNA repair pathways in the form of single nucleotide polymorphisms (SNPs) within vital DNA repair genes may result in insufficient DNA repair and increase in DNA breaks thus rendering the human system vulnerable to the debilitatory effects of grave diseases like cancers. The present study involves investigation of association of the non-synonymous SNP rs1052133 (C8069G/Ser326Cys) located in the exonic region of the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head and neck (SCCHN).

Methods:

Case-control based genetic association study was performed among 575 (250 SCCHN cases and 325 normal healthy controls) sub-population cluster-matched (Indo-Europeans linguistic subgroup + Caucasoid morphological subtype) samples from the north Indian States of Uttar Pradesh and Uttarakhand using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing analysis.

Results:

Our results demonstrated statistically significant protective association for the heterozygous CG [Odds Ratio (OR) 0.6587, 95% Confidence Interval (CI) 0.4615 to 0.9402, P=0.0238], homozygous mutant GG (OR 0.2570, 95% CI 0.1070 to 0.6175, P=0.0013) and combined mutant CG + GG (OR 0.6057, 95% CI 0.4272 to 0.8586, P=0.0059) genotypes. Interpretation &

conclusions:

The results indicate that the polymorphism rs1052133 is strongly associated with SCCHN susceptibility and the mutant (G) allele might be a protective factor for SCCHN among north Indian subpopulations.
Asunto(s)

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Carcinoma / Carcinoma de Células Escamosas / Estudios de Casos y Controles / Factores de Riesgo / Neoplasias de Células Escamosas / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Bases de Datos Genéticas / ADN Glicosilasas Tipo de estudio: Estudio de etiología / Estudio observacional / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Carcinoma / Carcinoma de Células Escamosas / Estudios de Casos y Controles / Factores de Riesgo / Neoplasias de Células Escamosas / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Bases de Datos Genéticas / ADN Glicosilasas Tipo de estudio: Estudio de etiología / Estudio observacional / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Año: 2011 Tipo del documento: Artículo