Natamycin in the treatment of keratomycosis: Correlation of treatment outcome and in vitro susceptibility of fungal isolates.
Indian J Ophthalmol
;
2011 Nov; 59(6): 512-514
Artículo
en Inglés
| IMSEAR
| ID: sea-136241
ABSTRACT
In this study, 60 fungal isolates from 60 patients with fungal keratitis were tested in vitro for their susceptibility to natamycin and the mean minimum inhibitory concentrations of natamycin (MICn) were correlated with clinical outcome. The mean MICn for various groups of fungi from patients with either early (<10 days) or late (≥10 days) presentation was correlated with the outcome. Aspergillus flavus showed resistance to natamycin with a high mean MICn (>16 μg/ml). While the clinical response in all patients with early A. flavus keratitis was good it was poor in late cases (5/8 patients, 62.5%). Fusarium species, Acremonium species and dematiaceous fungi were sensitive with low mean MICn (Fusarium 5.7-7.2 μg/ml, Acremonium 5.7-6.8 μg/ml, dematiaceous (1.6-4 μg/ml). However, 46.6% (7/15) patients in Fusarium and 57.1% (4/7) in Acremonium group needed keratoplasty. We conclude that despite susceptibility of most fungal species causing keratitis to natamycin, the treatment outcome is poor in advanced fungal keratitis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Soluciones Oftálmicas
/
Humanos
/
Pruebas de Sensibilidad Microbiana
/
Infecciones Fúngicas del Ojo
/
Natamicina
/
Estudios Prospectivos
/
Farmacorresistencia Fúngica
/
Queratitis
/
Antifúngicos
Tipo de estudio:
Estudio observacional
Idioma:
Inglés
Revista:
Indian J Ophthalmol
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS