Antioxidant status in children with homozygous thalassemia.
Indian Pediatr
;
2005 Nov; 42(11): 1141-5
Artículo
en Inglés
| IMSEAR
| ID: sea-13754
ABSTRACT
The status of enzymatic and non-enzymatic anti-oxidants was evaluated in 41 patients with transfusion dependent beta-thalassemia. An additional 20 age-matched children, with non-hemolytic anemia, served as controls. Fresh blood samples, obtained in the morning, were processed immediately. Plasma was stored at -80 degrees C. Levels of vitamins A and E were assayed simultaneously by HPLC. RBC vitamin A was not measurable in 29 (70.7%) thalassemics and in all the controls. Plasma vitamin A levels were lower in thalassemics than in controls (p<0.05). Vitamin E in RBCs was not measurable in 13 (31. 7%) cases. The mean level of RBC vitamin E was 3 times lower in thalassemics. Similarly, SOD enzyme activity in thalassemics, was at least 1.5 lower in comparison to the activity documented in controls (p<0. 05). The observations indicate that thalassemics have enhanced oxidative stress. Administration of selective antioxidants and a balanced diet may preclude oxidative damage.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Superóxido Dismutasa
/
Vitamina A
/
Vitamina E
/
Femenino
/
Humanos
/
Masculino
/
Niño
/
Talasemia beta
/
Eritrocitos
Idioma:
Inglés
Revista:
Indian Pediatr
Año:
2005
Tipo del documento:
Artículo
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