The study of birth defects in the newborns at Siriraj Hospital (1990-1991).

ABSTRACT

The study of congenital malformation or birth defects in newborn infants at Siriraj Hospital from September 1990 – September 1991 found 161 newborns with congenital malformation out of 18,958 infants delivered which is 0.9 percent. These were 1.21 ratio of males to females. Ninety-five percent were considered malformation. Deformation, disruption and dysplasia were found to be 1.6 percent in each category. The most common malformation were musculoskeletal, central nervous system and gastrointestinal system respectively. This finding was similar to study from Children’s Hospital in 1989. Other congenital malformation was categorized differently. The etiologies of congenital malformation were as follow 37.4 percent of unknown etiology, 36 percent were multifactorial, 12.4 percent were chromosomal, 6.1 percent were single gene disorders, 6.1 percent were teratogenesis and 2 percent were intrauterine environmental factors.