Autologous blood and platelet-rich plasma reinfusion reduce post-operative blood and blood component therapy after cardiopulmonary bypass.

ABSTRACT

To study blood and blood component transfusion following reinfusion of platelet-rich plasma (PRP)/and autologous blood, 33 patients undergoing open-heart surgery were randomly divided into three groups. Group I comprised 13 patients as controls; group II, eight patients from whom were collected PRP 15-20 percent of plasma volume with Haemonetics; and group III, 12 patients from whom were collected PRP and whole blood (400-800 ml) before initiating standardized cardiopulmonary bypass. All of them had balanced anesthesia with thiopental, fentanyl, midazolam, atracurium and nitrous oxide in oxygen. After heparin reversal, PRP/PRP and autologous blood were reinfused in groups II and III, respectively. Recording of hematocrit, blood loss as well as the total number of transfusion was performed. In three groups, significant low levels of hematocrit were seen after cardiopulmonary bypass. Groups II and III has less blood loss after the operation as well as less banked blood and blood products transfusion (p<0.05). In conclusion, the reinfusion of PRP/PRP and autologous blood may serve as an effective method for reducing the amount of banked blood and blood products given in transfusion following cardiac operation.