Elevated serum gamma-glutamyl transferase and other enzymes in alcoholic.

ABSTRACT

Serum from a total of 119 workers from Thailand Tobacco Monopoly Company were studied. The subjects were divided into three groups control, alcoholic who smoke. The enzymatic activities of serum gamma-glutamyl transferase, alkaline phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase were determined. The average enzymatic activity in all three groups was found within normal limits. Individual with alcohol consumption showed higher enzymatic activities of serum gamma-glutamyl transferase (p<0.0005), alkaline phosphatase (p<0.05), glutamic oxaloacetic transaminase (p<0.0005) and glutamic pyruvic transaminase (p<0.0005) when compared with controls. There was no significant difference in the ratio of glutamic oxaloacetic transaminase to glutamic pyruvic transaminase in alcoholics compared with controls. While the ratio of gamma-glutamyl transferase to glutamic oxaloacetic transaminase in alcoholics was significantly higher (p<0.0005) when compared with controls.