Perioperative challenges in a patient of severe G6PD deficiency undergoing open heart surgery.
Ann Card Anaesth
;
2012 Jan; 15(1): 50-53
Artículo
en Inglés
| IMSEAR
| ID: sea-139635
ABSTRACT
We describe a successful perioperative management of a case of 38-year-old male, presented with chronic jaundice with severe mitral stenosis and moderate tricuspid regurgitation; upon evaluation, he was found to have severe glucose-6-phosphate dehydrogenase (G6PD) deficiency. Usually, patients deficient in G6PD exhibit increased hemolysis andtherefore increased need for blood transfusion after cardiac surgery as well as impaired oxygenation in the postoperative period leading to prolonged ventilation. On reperfusion after a period of ischemia, the antioxidant system recruits all of its components in an attempt to neutralize the overwhelming oxidative stress of free radicals, as the free radical scavenging system is deficient in these patients, the chances of free-radical-induced injury is more. Our patient underwent mitral valve replacement and tricuspid annuloplasty under cardiopulmonary bypass with necessary precautions to reduce the formation of free radicals. Treatment was targeted toward theprevention of free radical injuryin the G6PD-deficient patient. He had an uneventful intraoperative and postoperative course.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Cuidados Preoperatorios
/
Humanos
/
Masculino
/
Puente Cardiopulmonar
/
Adulto
/
Deficiencia de Glucosafosfato Deshidrogenasa
/
Procedimientos Quirúrgicos Cardíacos
Idioma:
Inglés
Revista:
Ann Card Anaesth
Año:
2012
Tipo del documento:
Artículo
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