Lycopene in the management of oral lichen planus: A placebo-controlled study.
Artículo
en Inglés
| IMSEAR
| ID: sea-140101
ABSTRACT
Context Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported. Aim:
This study was designed to assess the efficacy of systemic lycopene in the management of OLP. Settings andDesign:
This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India. Materials andMethods:
Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer's Exact test.Results:
A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group.Conclusion:
Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Placebos
/
Dimensión del Dolor
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Inducción de Remisión
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Carotenoides
/
Método Doble Ciego
/
Estudios Prospectivos
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Año:
2011
Tipo del documento:
Artículo
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