Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt.
Indian J Pathol Microbiol
;
2012 Jan-Mar 55(1): 56-60
Artículo
en Inglés
| IMSEAR
| ID: sea-142177
ABSTRACT
Background and Objective:
Psoriasis is a chronic inflammatory skin disease characterized by hyper-proliferation, abnormal differentiation, and inflammatory infiltration in epidermis and dermis. We planned this study to analyze probable associations between Osteopontin (OPN), Ki-67, CD34, and histopathological features in psoriasis. Materials andMethods:
We studied OPN expression and its correlation with Ki-67 and CD34 expression in lesional, non-lesional skin, and normal skin. Immunoreactivity for OPN and Ki-67 was based on the level of epidermal staining. CD34 expression was scored as mild, moderate, and strong, according to the number of stained dermal capillaries.Results:
Our results showed statistically significant differences in the expression of OPN, Ki-67, and CD34 between lesional and non-lesional skin as well as between non-lesional skin and control group (P≤0.001). In addition, there was a significant difference in the expression of OPN, Ki-67, and CD34 between control and lesional group (P=0.02, P=0.02, and P=0.04, respectively).Conclusions:
OPN expression seems to be related to Ki-67 (proliferation index) and CD34 expression (angiogenesis marker) confirming its role in the pathogenesis of psoriasis. Then "anti- OPN and anti-angiogenesis" may eventually become a useful therapeutic approach in psoriasis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Psoriasis
/
Piel
/
Femenino
/
Humanos
/
Masculino
/
Inmunohistoquímica
/
Niño
/
Adolescente
/
Antígenos CD34
/
Antígeno Ki-67
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
Indian J Pathol Microbiol
Año:
2012
Tipo del documento:
Artículo
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