Pediatric disorders of sex development.
Indian J Pediatr
;
2009 Sept; 76(9): 956-958
Artículo
en Inglés
| IMSEAR
| ID: sea-142381
ABSTRACT
The management of disorders of sexual differentiation (DSD) involves a multidisciplinary approach. The main aim of analysis was to study the phenotype-karyotype correlation in North Indian children with DSD. The records of pediatric DSD were retrieved and characteristics noted. Of total of 58 children, 43 (74.1%) and 10 (17.2%) were raised as males and females respectively. The mean age at presentation was 31.3±9 months. The karyotype was 46XY in 45 (77.6%) and 46XX in 12 (20.7%). CAH was commonest cause of DSD (36.2%), followed by gonadal dysgenesis. Of the 15 patients of 46 XY CAH, there were 5 with 17-α hydroxylase deficiency, 2 with 3-β HSD deficiency and one case of lipoid adrenal hyperplasia. There was an excess of genetic males, possibly due to prevalent socio-cultural factors and gender bias favoring males. There is a need to improve the diagnostic facilities and incorporate a team approach in management of DSD.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fenotipo
/
Trastornos del Desarrollo Sexual
/
Femenino
/
Humanos
/
Masculino
/
Distribución de Chi-Cuadrado
/
Preescolar
/
India
/
Lactante
/
Cariotipificación
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Pediatr
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS