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Prevalence and hematological profile of β-thalassemia and sickle cell anemia in four communities of Surat city.
Indian J Hum Genet ; 2012 May; 18(2): 167-171
Artículo en Inglés | IMSEAR | ID: sea-143265
ABSTRACT

Background:

From the data of transfusion-dependent thalassemia major cases, the 4 communities (Muslim, Dhodia Patel, Kachhiya Patel, and Modh Bania) with high prevalence but not studied methodically were selected.

Aim:

The aim of this study is to find prevalence of β-thalassemia and sickle cell anemia in 4 selected communities and also to evaluate hematological profile in them. Materials and

Methods:

For screening of β-thalassemia trait (BTT) and sickle cell trait (SCT), all samples were tested for red cell indices, solubility, HbA 2 level and doubtful cases confirmed on HPLC. Statistical

Analysis:

Mean ± SD, χ2 and 't' tests were used to evaluate the significance. Results and

Conclusion:

Among 4 selected communities, the highest prevalence of BTT was observed in Modh Bania (6.2%) and Kachhiya Patel (6.05%) and that of SCT in Dhodia Patel (14.0%). Significantly higher prevalence of BTT was observed in Memon ( P < 0.0001) and of SCT in Khalifa 6.6% ( P < 0.0001) compared to other Muslim sub castes. Anemia was more prevalent in BTT compared to non-BTT and non-SCT subjects. 80% of Dhodia Patel non-BTT and non-SCT subjects showed microcytic red cell morphology. Their Mean ± SD Hb concentration was 12.1 ± 1.73, hence iron deficiency cannot be a sole reason. This community needs α-thalassemia and iron studies.
Asunto(s)

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Femenino / Humanos / Masculino / Etnicidad / Características de la Residencia / Prevalencia / Adolescente / Talasemia beta / Grupos de Población / Adulto Joven Tipo de estudio: Estudio de prevalencia / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Revista: Indian J Hum Genet Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Femenino / Humanos / Masculino / Etnicidad / Características de la Residencia / Prevalencia / Adolescente / Talasemia beta / Grupos de Población / Adulto Joven Tipo de estudio: Estudio de prevalencia / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Revista: Indian J Hum Genet Año: 2012 Tipo del documento: Artículo