Prevalence and hematological profile of β-thalassemia and sickle cell anemia in four communities of Surat city.
Indian J Hum Genet
;
2012 May; 18(2): 167-171
Artículo
en Inglés
| IMSEAR
| ID: sea-143265
ABSTRACT
Background:
From the data of transfusion-dependent thalassemia major cases, the 4 communities (Muslim, Dhodia Patel, Kachhiya Patel, and Modh Bania) with high prevalence but not studied methodically were selected.Aim:
The aim of this study is to find prevalence of β-thalassemia and sickle cell anemia in 4 selected communities and also to evaluate hematological profile in them. Materials andMethods:
For screening of β-thalassemia trait (BTT) and sickle cell trait (SCT), all samples were tested for red cell indices, solubility, HbA 2 level and doubtful cases confirmed on HPLC. StatisticalAnalysis:
Mean ± SD, χ2 and 't' tests were used to evaluate the significance. Results andConclusion:
Among 4 selected communities, the highest prevalence of BTT was observed in Modh Bania (6.2%) and Kachhiya Patel (6.05%) and that of SCT in Dhodia Patel (14.0%). Significantly higher prevalence of BTT was observed in Memon ( P < 0.0001) and of SCT in Khalifa 6.6% ( P < 0.0001) compared to other Muslim sub castes. Anemia was more prevalent in BTT compared to non-BTT and non-SCT subjects. 80% of Dhodia Patel non-BTT and non-SCT subjects showed microcytic red cell morphology. Their Mean ± SD Hb concentration was 12.1 ± 1.73, hence iron deficiency cannot be a sole reason. This community needs α-thalassemia and iron studies.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
Etnicidad
/
Características de la Residencia
/
Prevalencia
/
Adolescente
/
Talasemia beta
/
Grupos de Población
/
Adulto Joven
Tipo de estudio:
Estudio de prevalencia
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Hum Genet
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS