Colistin against colistin-only-susceptible Acinetobacter baumannii-related infections: Monotherapy or combination therapy.
Indian J Med Microbiol
;
2012 Oct-Dec; 30(4): 448-452
Artículo
en Inglés
| IMSEAR
| ID: sea-144008
ABSTRACT
Purpose:
To evaluate the outcomes of the patients who were infected with colistin-only-susceptible (COS) Acinetobacter baumannii and treated with either colistin monotherapy or colistin combined therapy. Materials andMethods:
This retrospective case-control study was conducted in the training and research hospital with an 800 beds between August 2008 and December 2011. The patients, who were infected with COS A. baumannii and received either colistin monotherapy or colistin combined therapy, were included into the study.Results:
In total, 51 patients fulfilling study criteria were evaluated. Colistin monotherapy was found effective as much as colistin combined therapy in terms of clinical and microbiological responses in patients with ventilator associated pneumonia (VAP) and also in patients with blood stream infections.Conclusion:
Although there is no randomised controlled study yet, colistin monotherapy and colistin combined therapy are likely to achieve similar treatment responses rates. Heteroresistant strains can emerge in patients who receive colistin monotherapy.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pacientes
/
Humanos
/
Infecciones por Bacterias Gramnegativas
/
Colistina
/
Farmacorresistencia Bacteriana
/
Acinetobacter baumannii
/
Quimioterapia Combinada
/
Neumonía Asociada al Ventilador
/
Antibacterianos
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
/
Factores de riesgo
Idioma:
Inglés
Revista:
Indian J Med Microbiol
Asunto de la revista:
Microbiology
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS