A pilot study to determine genetic polymorphism in Mycobacterium tuberculosis isolates in Central India.
Indian J Med Microbiol
;
2012 Oct-Dec; 30(4): 470-473
Artículo
en Inglés
| IMSEAR
| ID: sea-144013
ABSTRACT
This study was carried out to identify predominant spoligotypes responsible for transmission and prevalence of tuberculosis in central India since there is no data available about the genetic biodiversity of Mycobacterium tuberculosis isolates from patients with tuberculosis in this region. 35 strains of Mycobacterium tuberculosis were subjected to spoligotyping according to the standard protocol. A total of 25 strains out of the 35 (71.42%) could be grouped in to 6 clusters. The largest cluster comprised 8 isolates. Unique (Non-clustered) spoligotypes were seen in 10 isolates, Nine strains did not match the data base (Spol DB-4 data base). The results indicate that there may be a number of orphan strains unique to this geographical area. Further studies on a larger sample size derived from this area would help us delineate the epidemiology of Mycobacterium tuberculosis infection in this area.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Polimorfismo Genético
/
Tuberculosis
/
Humanos
/
Técnicas de Tipificación Bacteriana
/
Técnicas de Genotipaje
/
Centros de Atención Terciaria
/
India
/
Mycobacterium tuberculosis
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Med Microbiol
Asunto de la revista:
Microbiology
Año:
2012
Tipo del documento:
Artículo
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