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Cetuximab with radiotherapy in patients with loco-regionally advanced squamous cell carcinoma of head and neck unsuitable or ineligible for concurrent platinum-based chemo-radiotherapy: Ready for routine clinical practice.
Indian J Cancer ; 2011 Apr-Jun; 48(2): 148-153
Artículo en Inglés | IMSEAR | ID: sea-144443
ABSTRACT

Purpose:

To report outcomes of cetuximab concurrent with radiotherapy in advanced head-neck cancer unsuitable for platinum-based chemo-radiotherapy. Materials and

Methods:

Retrospective chart review of 37 patients treated with cetuximab and radiotherapy at a comprehensive cancer centre.

Results:

Median age of study cohort was 59 years. Thirty four (92%) patients had advanced stage disease (stage III-IV). Reasons for ineligibility for platinum included impaired creatinine-clearance, old age, and/or co-morbidities. Thirty-two (86%) patients completed planned radiotherapy without interruption; 29 (80%) patients received ≥6 cycles of cetuximab. Fifteen patients (40.5%) developed ≥grade 3 dermatitis; 9 patients (25%) experienced ≥grade 3 mucositis. At a median follow-up of 16 months, the 2-year loco-regional control, disease-free survival, and overall survival was 35.5%, 29.5%, and 44.4% respectively. Stage grouping and severe dermatitis were significant predictors of outcome.

Conclusions:

Cetuximab concurrent with radiotherapy is a reasonable alternative in advanced head-neck cancer patients with acceptable compliance and outcomes, but higher skin toxicity.
Asunto(s)

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Anciano de 80 o más Años / Braquiterapia / Anciano / Femenino / Humanos / Masculino / Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Tasa de Supervivencia / Estudios Prospectivos Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Aged80 Idioma: Inglés Revista: Indian J Cancer Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Anciano de 80 o más Años / Braquiterapia / Anciano / Femenino / Humanos / Masculino / Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Tasa de Supervivencia / Estudios Prospectivos Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Aged80 Idioma: Inglés Revista: Indian J Cancer Año: 2011 Tipo del documento: Artículo