Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.
Indian J Exp Biol
;
2010 Mar; 48(3): 314-317
Artículo
en Inglés
| IMSEAR
| ID: sea-144974
ABSTRACT
Hexane, chloroform and ethyl acetate extracts (100 µg/ml) of Alpinia galanga rhizomes exhibited significant activity in vitro against promastigotes of L. donovani. Twelve compounds namely, methyleugenol (1), p-coumaryl diacetate (2), 1'-acetoxychavicol acetate (3), 1'-acetoxyeugenol acetate (4), trans-p-acetoxycinnamyl alcohol (5), trans-3,4-dimethoxycinnamyl alcohol (6), p-hydroxybenzaldehyde (7), p-hydroxycinnamaldehyde (8), trans-p-coumaryl alcohol (9), galangin (10), trans-p-coumaric acid (11) and galanganol B (12) were isolated from these extracts. Of these, compounds 2, 3, 4 and 5 were found most active in vitro against promastigotes of L. donovani with IC50 values of 39.3, 32.9, 18.9 and 79.9 µM respectively. This is the first report of antileishmanial activity of the extracts and isolated constituents of A. galanga.
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Índice:
IMSEAR (Asia Sudoriental)
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2010
Tipo del documento:
Artículo
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