Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine.
Indian J Exp Biol
;
2012 Jan; 50(1): 51-55
Artículo
en Inglés
| IMSEAR
| ID: sea-145222
ABSTRACT
Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole -induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs.
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Índice:
IMSEAR (Asia Sudoriental)
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2012
Tipo del documento:
Artículo
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