Lipid profiles with increase blood lead level: Risk of cardiovascular disease in battery workers of Lucknow City.

ABSTRACT

In order to investigate the effects of lead exposure on risk of cardiovascular disease during Occupational battery workers i.e. lead exposure, plasma cholesterol and its fractions as high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride (T.G.) were determined in various battery workers in Lucknow city U.P., India. Increased risk of cardiovascular disease was observed in the various battery workers. Total cholesterol in the battery workers and control group was 142.14±31.92 (mg/dl) and 95.72±11.57 (mg/dl) respectively, which is higher in the battery workers than that of present in control group, While LDL cholesterol in the battery workers and control group was 158.30±22.70 (mg/dl) and 103.77± 4.62 (mg/dl) respectively. HDL cholesterol in the battery workers and control group was 38.80±10.13 (mg/dl) and 65.53±6.52 (mg/dl) respectively. The triglyceride levels were 162.06±90.85 (mg/dl) and 138.62±5.65 (mg/dl) in the battery workers and control group respectively, which is not affected [p > 0.05]. The LDL/HDL and Total cholesterol/HDL cholesterol ratio, Blood pressure, and blood lead level, was also higher in the battery workers, Results suggest that lead exposure increases cholesterol synthesis and transport to peripheral tissues whereas reverse cholesterol transport to the liver is not affected.