Sonic hedgehog inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm.
Indian J Exp Biol
;
2013 Mar; 51(3): 201-207
Artículo
en Inglés
| IMSEAR
| ID: sea-147583
ABSTRACT
In the experimental group (shh inhibited group), there were significant decreases in the expression of Oct4, Nanog, Shh, GATA4, Brachyury and Goosecoid, while increases were observed for TAT and Pdx1. The expression of Sox17 did not differ between two control and experimental groups. In experimental group, the amount of GSC positive cells was somehow lower but it seems that there was no difference for Sox17. Shh inhibition induces ESCs to differentiate toward definitive endoderm by committing mesendodermal lineages.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Inmunohistoquímica
/
Diferenciación Celular
/
Línea Celular
/
Cartilla de ADN
/
Proteínas de Homeodominio
/
Regulación del Desarrollo de la Expresión Génica
/
Linaje de la Célula
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Ditizona
/
Endodermo
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2013
Tipo del documento:
Artículo
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