Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats.
Indian J Exp Biol
;
2013 Mar; 51(3): 256-261
Artículo
en Inglés
| IMSEAR
| ID: sea-147590
ABSTRACT
The efficacy of lawsone against L-arginine induced acute pancreatitis was determined at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α, C-reactive proteins and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite. The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Páncreas
/
Pancreatitis
/
Arginina
/
Ratas
/
Masculino
/
Proteína C-Reactiva
/
Enfermedad Aguda
/
Citocinas
/
Naftoquinonas
/
Interleucinas
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2013
Tipo del documento:
Artículo
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