Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis—a dose response study in rats.
Indian J Exp Biol
;
2013 Apr; 51(4): 292-302
Artículo
en Inglés
| IMSEAR
| ID: sea-147595
ABSTRACT
A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1β and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Peso Corporal
/
Masculino
/
Benzoquinonas
/
Ratas Wistar
/
Peroxidasa
/
Estrés Oxidativo
/
Interleucina-18
/
Etanol
/
Relación Dosis-Respuesta a Droga
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2013
Tipo del documento:
Artículo
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