Isolation of Mucilage from Cydonia vulgaris Pers. Seeds and its Evaluation as Superdisintegrant.

ABSTRACT

Gums and mucilages are preferably used as they are natural materials, for formulating conventional and novel dosage formulations. Natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, bio degradable and available in sufficient quantities. The study elaborates isolation of mucilage from the seeds of Cydonia vulgaris Pers. and explores it as tablet disintegrant. The mucilage was evaluated for all the parameters viz. solubility, swelling index, loss on drying, total ash, acid insoluble ash, microbial load and pH as per official monographs. The results confirmed that evaluation parameters were well within the limits. The disintegrating efficiency of isolated mucilage was equivalent to cross-povidone . The prepared batches were evaluated for hardness, friability, % drug content, wetting time, water absorption ratio and in vitro dispersion time. The results of isolated mucilage from Cydonia vulgaris Pers. were very promising.