Supporting the immune system through functional modulation of carbon tetrachloride intoxicated splenic macrophages by administering Tinospora cordifolia.
Artículo
en Inglés
| IMSEAR
| ID: sea-151306
ABSTRACT
The suppression of immune system leads to the development of several chronic illnesses; in replying to this the available allopathic system of medicine is provided with limited tools for treatment and prevention. In this context, the present investigation focuses on immunostimulant properties of an aqueous extract of Tinospora cordifolia in splenic macrophages isolated from carbon tetrachloride induced immunosuppressive mice. Our results suggested that carbon tetra chloride intoxication (0.5ml/Kg body weight) significantly altered the functional status like morphology, cell adhesion, phagocytosis, myeloperoxidase (MPO) release, nitric oxide (NO) release, DNA fragmentation and killing capacity of splenic macrophages. However administration of aqueous fraction of Tinospora cordifolia stem parts at a dose of 40 mg/kg body weight (in vivo) in CCl4 intoxicated male albino mice ameliorated the effect of CCl4, as was evident from the scanning electron micrographs, percentage of morphologically altered macrophages, phagocytosis activity, cell adhesion, MPO release, NO release, DNA fragmentation and intracellular killing capacity. Thus, it has been coclude that bioactive compounds presents in polar fractions of Tinospora cordifolia were accountable for boosting the immune system.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Idioma:
Inglés
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS