Study of C Reactive Protein in Type 2 Diabetes and its Relation with Various Complications from Eastern India.

ABSTRACT

Diabetes is associated with a pro-inflammatory state and endothelial dysfunction. Various markers of inflammation like C Reactive Protein (CRP) are elevated significantly in diabetic population. The levels of these markers also correlate with the severity of diabetes and presence of various complications. We therefore undertook this study to find the CRP levels in type 2 diabetes and its relation with other parameters. We selected only newly diagnosed drug naïve type 2 diabetes patients. Besides clinical examination, various blood tests including lipid profile and HbA1C were done. CRP levels were done by immunoturbidimetric method and the levels were compared among different subsets of patients. We had total of 80 patients (M F 4733). Dyslipidemia was the commonest complication (n=66) followed by nephropathy. Patients with cardiac and retinal complications had significantly higher levels of CRP. The presence of any 1 diabetic complication was associated with significantly higher CRP levels (1.8± 1.32 mg/dl vs. 0.49± 0.22; p <0.05 by t test). CRP levels showed significant positive correlation with serum triglyceride and HbA1C. CRP was associated with various diabetic complications. It was also related with the severity of glycemic status, as evidenced by HbA1C. Although our study was cross sectional, still, it showed correlation of CRP with many complications of diabetes and thus this can be an effective marker of clinical status in diabetes.